AGT encodes preangiotensinogen in the liver, which is subsequently cleaved by renin to generate angiotensin I. Angiotensin I converting enzyme, Semaxanib converts angiontensin I to angiotensin II, a potent vasoconstrictor that also affects renal hemodynamics by decreasing renal cortical blood flow, total renal plasma flow, urinary sodium excretion, and GFR. Moreover, angiotensin II increases glomerular capillary pressure, potentially contributing to glomerulosclerosis. AGT_rs4762 is a probably damaging SNP as it substitutes a non-polar amino acid for a polar amino acid. Furthermore, threonine at this position in AGT is highly conserved among divergent species ranging from human to zebrafish. Previous studies in Asians have identified associations of AGT_rs4762 with diabetic nephropathy in Taiwanese patients and hypertension in different Asian populations based on meta-analysis. We also found significant associations with eGFR for four correlated SNPs in the ACE gene, another key player in the RAS pathway of blood pressure regulation. Three of these SNPs are exonic variants, but do not cause amino acid substitutions. ACE_rs4343, was previously reported to be significantly associated with diabetic nephropathy in an Asian Indian population. Our analysis identified a significant association of eGFR with two intronic SNPs in the adducin 1 gene. ADD1 encodes the alpha subunit of the cytoskeleton protein adducin. Many previous studies have reported associations of ADD1 variants with hypertension, renal functions and renal diseases, in different populations including Chinese. Another SNP that showed associations in our study was rs2488815, an intronic SNP in the G protein_coupled receptor kinase 4 gene, a major player in sodium homeostasis and blood pressure regulation. GRK4 is expressed in the renal proximal tubule, where about 70% of renal sodium reabsorption takes place. Increased GRK4 activity leads to decreased dopamine signaling and increased AngII receptor expression and function, both of which increase sodium retention and blood volume which ultimately leads to hypertension. GRK4 variants have been shown to be associated with hypertension and blood pressure traits in different populations including Han Chinese. ADRB2 SNPs were previously found to be associated with hypertension and blood pressure traits in different populations including Han Chinese but many of the results are inconsistent. ADRB2_rs1042718, the SNP showing significant GxG interaction, is part of a haplotype recently found to be associated with weight, insulin, and homeostasis model assessment score in Korean adolescents. The exact mechanism of interaction between these two coding region SNPs in relation to eGFR warrants further investigation. We compared the results of our association study with a recently published meta-analysis of kidney function traits in several East Asian populations, including GenSalt. The SNPs with significant associations in our study were not significantly associated with eGFR in the meta-analysis.