l wounding of Arabidopsis leaves led to an increase in JA-Ile, which is preceded by a large increase in free JA. So, the wounding of A. annua plants could increase the content of endogenous JA, while the increased endogenous JA may promote the biosynthetic pathway of artemisinin. The presumption were consistent with the results of Liu et al., which showed that wounding stress can significantly elevate the artemisinin content by increasing the expression levels of some key genes in artemisinin biosynthetic pathway. High level of JA can inhibit the root Ginsenoside-Ro growth in growth medium. We observed the phenotypes of the control and AaAOC-overexpression lines. The growth of AaAOC-overexpression lines were only slightly changed versus the control. So, we inferred that the concentrations of JA should reach to a high level which could result in the significant decrease of root growth and plants�� growth. Meas et 
al. showed that exogenous JA treatments promoted the expression levels of artemisinin biosynthetic pathway, which ultimately led to increased artemisinin accumulation in A. annua. However, the significance and function of endogenous JA in artemisinin biosynthetic pathway remain unknown in A. annua. The results of RT-Q-PCR showed that, compared to the control level, the transcript levels of FPS, CYP71AV1 and DBR2 were increased significantly in AaAOC-overexpression transgenic A. annua, while ADS, CPR and ALDH1 were barely or only slightly changed. The results of HPLC showed that sesquiterpenoids accumulation significantly increased in AaAOC-overexpression transgenic A. annua. Interestingly, AOC-1, which has the highest content of endogenous JA, had the highest expression levels of FPS and DBR2 in transgenic A. annua plants. The contents of artemisinin and dihydroartemisinic acid in AOC-1 were also the highest in transgenic A. annua plants. From the above results, we concluded that the increased endogenous JA significantly promoted the expression levels of some key genes in artemisinin biosynthetic pathway and resulted in the increase of sesquiterpenoids accumulation in AaAOC-overexpression transgenic A. annua. There is growing interest in neurofeedback as a treatment for a variety of mental disorders including ADHD, anxiety, and depression. It is postulated that this technique, within an operant conditioning framework, helps individuals to regulate cortical electroencephalographic activity while Tubeimoside-I receiving feedback from a visual or acoustic signal. The resulting change in EEG activity is associated with a change in underlying cortical activation, and subsequently to result in a reduction of associated symptoms. On an electrophysiological level, major depressive disorder appears to be associated with relatively more left than right resting activity in prefrontal regions, although some inconclusive studies exist in MDD. To avoid confusion, it should be underlined that increased alpha activity in cortical structures is indicative of decreased cortical activation in those areas. AA is thought to represent reduced approach-related behaviours and reduced sensitivity to rewards in MDD.