Further, in terms of plant science, specific plant SN-38 secondary metabolites are expected to be revealed as candidate active compounds for anti-inflammatory, anti-colitis therapies. We hypothesize that these ��medicinal�� secondary metabolites may also confer useful anti-stress and pro-innate immunity bioactivities in host plants, due to the orthologous molecular and cellular mechanisms seen in plants. These mechanisms may well be mirrored in mammalian systems. The possible effects of this specific class of secondary plant metabolites from Wedelia may hence warrant further systematic investigation in the future. It has been proven to have a direct cytotoxic effect on a wide range of cancer cell lines in vitro. It has been reported that melittin inhibited cell growth in two ovarian cancer cells via induction of death receptors and down regulation ofJAK2/STAT3. It exerts its toxic activity by disrupting plasma membranes following pore formation. Cationica a residues of melittin interact directly with anionic cellular membranes via electrostatic interactions and hydrophobic regions; this interaction is responsible for membrane permeation and disruption. A comparably short protein, with an end-to-end Pridinol Methanesulfonate distance of~3.5 nm, the dimension perfectly serves as a single transmembrane-spanning alpha-helix. Numerous computational studies have demonstrated that melittin forms transmembrane pores from its interaction with lecithin PC membranes. Its potent activity has attracted researchers to utilize melittin for the next generation anticancer therapeutic agent. However, the therapeutic potential has not been fully achieved in clinic due to their off-target toxicity, rapid degradation and clearance in vivo. Melittin has been incorporated into lipid coated perfluorocarbon particles to accumulate in multiple tumor targets, dramatically reducing tumor growth. Although a few of these approaches clearly promise impending success in preclinical studies, their translational potential has not been fully realized. None or very little information can be found in the literature regarding their translational use in human studies.