All four of the breast (-)-Sparteine-sulfate-pentahydrate cancer cell lines that lost miR-200c and miR-141 expression have an aberrantly methylated mir-200c/141 CpG island, and each of these cell lines displays a mesenchymal phenotype. In contrast, those breast cancer cell lines that express miR-200c and miR-141 and have an unmethylated CpG island display an epithelial phenotype. A similar picture emerges in the prostate cancer cell lines. The PC3 cells that have lost miR-200c and miR-141 expression, display an aberrantly methylated CpG island and a mesenchymal Germacrone phenotype, whereas LnCaP and Du145 retain miR-200c and miR-141 expression and an epithelial phenotype. These results suggest that DNA methylation may control the phenotypic changes observed in cancer cells. Age-related macular degeneration is a highly prevalent cause of severe vision impairment among people aged 55 years and older. It is a degenerative disorder of the central retina involving predominantly the rod photoreceptors, the retinal pigment epithelium, Bruchs membrane and the underlying choriocapillaris. The disease aetiology is complex and is influenced by a combination of multiple genetic susceptibility factors and environmental components. An early sign of AMD is the appearance of drusen, yellowish extracellular deposits of protein and lipid material within and beneath the RPE. Advanced AMD manifests essentially as two distinct late-stage lesions �C geographic atrophy and neovascular AMD. GA occurs in up to 50% of cases and is clinically defined as a discrete area of RPE atrophy with visible choroidal vessels in the absence of neovascularization in the same eye. It may or may not involve the fovea. NV AMD describes the development of new blood vessels beneath and within the retina and is characterized by serous or hemorrhagic detachment of either the RPE or the sensory retina, the presence of subretinal fibrous tissue and eventually widespread RPE atrophy. Progression to visual loss can be rapid in NV AMD.The precise aetiology of AMD is still not fully understood, although risk factors such as age, smoking, and genetic components are known to strongly contribute to disease development.