IGF2 is a polypeptide growth factor that plays an LM11A-31 dihydrochloride important role in growth and development, and it stimulates insulin action. IGF2BP1 binds to the leading 3 mRNA in the 59-UTR of the IGF2 gene to regulate IGF2 translation. However, the biological function of IGF2BP2 is not well-studied. Previous studies have shown that the T allele of the SNP rs4402960 was a risk factor for diabetes. In the present study, we found no statistically BC8-15 significant association between rs4402960 and diabetes. However, variant allele T was negatively associated with overweight. To our knowledge, this is the first study that reports such a protective association of this SNP with overweight. In the study by Xia Li et al, rs11705701, a SNP in strong LD with rs4402960, was identified to be associated with percent body fat in Mexican Americans. In addition, SNP rs2237892 located within gene KCNQ1 was found to be associated with both overweight and obesity and diabetes at first. Variant allele T of rs2237892 was associated with a higher prevalence of overwight, but was with a lower prevalence of diabetes in our study, which was consistent with previous studies. Biologically, KCNQ1 is a gene encoding the poreforming subunit of a voltage-gated K+ channel that plays a key role in the repolarization of the cardiac action potential as well as water and salt transportation in the beta cells. KV-channel knock-out in rat islets as well as pharmacological inhibition of KVchannels in rat beta cells have been reported to enhance glucosestimulated insulin secretion. Meanwhile, IGF2BP2 were also associated with reductions in first-phase insulin secretion in some studies. Moreover, both SNPs were located at 11p15 of chromosome, variants of which were confirmed to be associated with the Beckwith-Wiedemann syndrome. The associations mentioned above suggested a possible interaction between rs4402960 and rs2237892 for overweight and obesity in our study. We tested this interaction but found no statistical significance. Further studies of these two SNPs are necessary. INSIG1 and INSIG2 play important roles in regulating cholesterol or TG synthesis, mainly in the liver. rs7566605, which is located 10 kb upstream of INSIG2, was reported to have the strongest association with obesity among 86 604 SNPs.