However, the exact morbid conditions induced by high systemic levels of IL-1 during severe diseases with persistent and intensive epidermis injury remains largely unknown. We addressed this problem by using keratin-14 driven caspase-1 transgenic mice and a keratinocyte-specific mature IL-18-transgenic mice line that we have previously developed. Here, we show that KCASP1Tg and KIL-18Tg mice with dermatitis have severe pathology in systemic organs other than the skin including aberrant remodeling of fatty and connective tissues, and extensive amyloid deposition with organ dysfunction, and that these abnormalities improved with the use of anti IL-1a/b antibodies. Quinones are aromatic MSX-122 compounds naturally present in bacteria and eukaryotes. They are often BAR 501 impurity involved in the biochemistry of energy production and serve as vital links in electron transport in the form of ubiquinones. This biological activity is related to the acceptance of one and/or two electrons to form the corresponding radical anion or dianion species. Quinones are aromatic compounds naturally present in bacteria and eukaryotes. They are often involved in the biochemistry of energy production and serve as vital links in electron transport in the form of ubiquinones. This biological activity is related to the acceptance of one and/or two electrons to form the corresponding radical anion or dianion species. Quinones are also natural defensive products made by plants and have been employed as anti-fungal agents, broad-spectrum antibacterials, and anti-malarial drugs. Moreover, extensively substituted anthroquinones or p-benzoquinones or naphthoquinones with reactive or heterocyclic groups are effective anti-cancer agents forming one of the largest classes of cytotoxic agents used therapeutically against cancer. Quinones are particularly effective at inducing apoptosis and as such provide a rich source of unique cytotoxic reagents that can be exploited.