In this paper, we adopted a mixed sampling strategy to obtain the transcriptional profile of three vegetative tissues of the paper mulberry. About 54,638,676 Illumina reads were de novo assembled for the first time to build the transcriptome of the paper mulberry. Sequence information for those genes involved in the biosynthesis of flavonoids, cellulose and other compound can be used for metabolic engineering of the paper mulberry. The large number of transcripts reported in the current study additionally serves as an invaluable genetic resource for crop improvement of paper mulberry as well as other plants. Despite the important economic value of the paper mulberry, its transcriptomic and genomic data are not available in public databases. Illumina RNA-seq technology has been extensively used in the transcriptome sequencing for the model plants with reference genome data or non-model plants without reference genomic information. Here, we obtained for the first time the genome-wide expression profiling of the paper mulberry using the Illumina sequencing platform and the Trinity program. The bidirectional interaction between depression and ischemic heart disease has been documented numerous times and is generally accepted. After an acute myocardial infarction the risk of being depressed is approximately 3 times increased as compared with the general population. In out-patients the 12month odds ratio of major depression has been found to be 2.3 times higher in individuals with cardiac disease as compared with those with no medical illness. In initially healthy people clinical depression as well as depressive mood is associated with a significantly increased risk of developing IHD. Further, depression after a MI doubles both the risk of a cardiac re-event during the first years post MI, as well the risk of 2 years mortality. Depression, quality of life and general well-being is all part of the chronic stress concept. Stress is vaguely defined but is generally accepted as a risk factor for a poor outcome in IHD. Chronic stress is associated with cardiovascular re-events and death from IHD and patients with MI have been shown to have higher stress levels when measured both as stress at work, stress at home, financial stress and major life-event stress. Chronic stress and depression is associated with widespread increased pain sensitivity, leading to both hyperalgesia and allodynia. The increase in pain sensitivity might be due to the neuroplastic effects of chronic stress on pain circuitry i.e. the diffuse noxious inhibitory control system. DNIC is an endogenous pathway mediating inhibition of lamina I neurons in the spinal dorsal root when pain signals ascend from the periphery through sensory C fiber neurons distributed wide spread over the body in the epidermis and up through the spinal cord. Patients with hypersensitivity to pain have been shown to have an impaired DNIC modulation.