Although Th2 cells are dominant Noradrenaline bitartrate monohydrate during the acute phase of AD, IL-12- and interferon -c-producing Th1 cells are highly expressed and contribute to the pathogenesis during the chronic phase. For many years, AD therapeutic strategies have been dominated by the application of local or systemic corticosteroids. However, these steroids often produce adverse effects in patients with AD, and there is a great need to develop new and effective AD therapies. The NC/Nga mouse is the first reported spontaneously occurring AD model. Skin changes that closely mimic human AD are induced in NC/Nga mice following exposure to various environmental aeroallergens. It was reported that 2,4dinitrochlorobenzene, an electrophilic and cytotoxic benzene Regadenoson derivative, induces stable clinical AD-like skin diseases in NC/Nga mice. Skin changes in NC/Nga mice are evidenced by scratching behavior, followed by the rapid development of erythema, lichenification with edema, and hemorrhage. Histological examinations have revealed hyperplasia and dense accumulation of eosinophils and mast cells in skin lesions. Along with these skin changes, NC/Nga mice exhibit elevated levels of total serum IgE. DNCB-induced contact hypersensitivity pathogenesis is predominantly the result of T cellmediated immune responses. Daidzin and genistin are naturally occurring isoflavones that are highly concentrated in soybeans. Various experimental and clinical investigations have reported that natural immune modulators from herbal extracts or derivatives may have therapeutic effects on AD. Epidemiological studies suggest that soy isoflavones have beneficial effects on health, including antioxidant activity, cancer prevention, and enhanced immunity. The main soy isoflavone glucosides daidzin and genistin are hydrolyzed by intestinal microorganisms to the aglycones daidzein and genistein, respectively, prior to absorption. Daidzin and its metabolites have been shown to have cancer preventive effects ; however, there have been no reports of their possible anti-AD effects.While acceptable alignments are obtained for the pore domain, it is much harder to do the same for the S5-P1 and P2-S6 linker sequences in the turret because there are no good templates, and much less data are available on their function.