Osteoarthritis and rheumatoid arthritis are the most debilitating forms of arthritis. AC is the highly specialized connective tissue responsible for frictionless movement between the articulating joint surfaces and the transmission of loads with a low frictional coefficient.AC lacks blood vessels and lymphatic supply, has a limited capacity for intrinsic healing and repair, and has structural arrangements that are challenging for repair and restoration.Chondrocytes of AC are embedded in a matrix comprising type II collagen proteoglycans and water. Water comprises 60�C80% of the wet weight of cartilage. Biomechanical properties of collagen and proteogly can provide tensile and cushioning properties of AC, respectively. The destruction of the AC is associated with reduced synthesis of the matrix components by articular chondrocytes and the enhanced break down of the matrix by disintegrin and metalloproteinase with thrombospondin motifs and matrix metalloproteinases.The degradation of proteoglycan is an early and reversible process, where as the break down of the collagen network in AC by collagenases results in their reversible destruction of the fibrillar network. The treatment of arthritis involves different combinations of drugs offered at different stages of the disease to control inflammation and swelling by blocking the prime inflammatory processes. To date, no Sulfamethoxazole pharmacological intervention offers protection or treatment from destruction of AC in arthritic conditions. Polyphenols, many of which are well known for their antioxidant and anti-inflammatory activities, are consumed as Esomeprazole Magnesium micronutrients in the human diet, with an average consumption of 1g/day. Polyphenols taken orally are extensively metabolized in the intestinal and hepatic systems, and the metabolites in the plasma differ in their biological activities.Polyphenols are also an integral part of traditional medicines for the treatment of arthritis in many countries. Tannic acid extracted from oak trees also has beneficial biological activities in cancer and diabetes. Previous findings relating to the role of polyphenols in arthritis mostly elucidate the mechanisms of inhibiting inflammatory cytokines or MMPs.